The Critical Role of NAD+ in Aging

Aging is an inevitable biological process characterized not just by the passage of time, but by the gradual decline of various bodily systems. Recent scientific advancements have illuminated a fascinating connection between aging and cellular health, with nicotinamide adenine dinucleotide (NAD+) emerging as a pivotal player. This coenzyme, found in every cell of our body, underpins critical biological processes such as energy production, DNA repair, and epigenetic regulation, making it a cornerstone of healthy aging

The Science of NAD+: A Cellular Perspective

NAD+ and Cellular Functions

1. Energy Metabolism: NAD+ facilitates the conversion of nutrients into ATP, the cellular energy currency, within mitochondria. Research published in Cell Reports (2016) shows that higher NAD+ levels correlate with increased mitochondrial efficiency and energy production.

2. DNA Repair and Cellular Regulation: NAD+ acts as a helper molecule for sirtuins and PARPs, enzymes that repair damaged DNA and regulate gene expression. Studies in Science Advances (2019) demonstrate how NAD+ boosts PARP activity, reducing mutation rates and enhancing genomic stability.

Unfortunately, NAD+ levels decline with age. Research published in Nature Aging demonstrates that NAD+ levels drop significantly starting in middle age, reducing cellular efficiency and contributing to various age-related conditions.

Why NAD+ Levels Decline: Key Insights

Scientific Data

• A 2018 study in Cell Metabolism revealed a nearly 50% decline in NAD+ levels by middle age compared to youth.

• This reduction impairs sirtuin function, essential for longevity and DNA repair.

• Declining NAD+ leads to compromised mitochondrial ATP production and weaker DNA repair mechanisms (Nature Reviews Molecular Cell Biology, 2020).

  
  

The Impact of NAD+ Depletion

• Mitochondrial Dysfunction: Reduced ATP production leads to decreased cellular energy. A study in The Journal of Physiology (2020) observed that declining NAD+ levels directly correlate with muscle fatigue and reduced endurance.

• DNA Instability: Impaired repair processes accelerate cellular aging. Research in Molecular Cell (2017) highlights increased DNA breaks in low-NAD+ environments.

• Chronic Diseases: NAD+ depletion increases susceptibility to conditions like metabolic disorders and neurodegeneration. A longitudinal study published in The Lancet Neurology (2019) connected declining NAD+ to cognitive decline in Alzheimer’s patients.

  
  

Solutions: Restoring NAD+ Levels

The Role of Supplements

• Nicotinamide Riboside (NR): Clinical trials (Journal of Clinical Investigation, 2016) show NR supplementation restores NAD+ levels by 40-50%, improving mitochondrial function and reducing markers of cellular stress. NR has been shown to boost insulin sensitivity and muscle regeneration in older adults (Nature Communications, 2021).

• Pterostilbene: A bioavailable polyphenol enhances sirtuin activity and supports DNA repair. A 2020 study in Antioxidants found that pterostilbene reduces oxidative damage and inflammation, key contributors to aging.

  
  

Core Ingredients for Cellular Health

The CORE NAD+ Booster features Nicotinamide Riboside (NR-E) as its central ingredient, scientifically validated as one of the most effective NAD+ boosters available. Each serving contains 200 mg of NR-E, which plays a vital role in enhancing NAD+ production, supporting cellular energy metabolism, and promoting DNA repair. This advanced formula integrates additional powerful ingredients to maximize its anti-aging benefits.

Pterostilbene: A Potent Antioxidant

Pterostilbene, often called a "cousin" to resveratrol, boasts enhanced bioavailability, allowing it to remain active longer in the body. Key benefits include:

• Activating SIRT1 for DNA Maintenance: Studies in Frontiers in Aging Neuroscience (2020) demonstrate its ability to improve cognitive health by promoting neuronal resilience.

• Neutralizing Oxidative Stress and Inflammation: Reduces free radical damage, as evidenced in Free Radical Biology and Medicine (2018).

• Improving Cardiovascular Health: Pterostilbene has been shown to reduce arterial stiffness and improve blood lipid profiles (Journal of Cardiovascular Pharmacology, 2019).

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Rosemary Extract: Cellular Protection

Rosemary Extract provides:

• Antioxidant Properties to Reduce Lipid Peroxidation: Protects cellular membranes, as highlighted in Phytomedicine (2020).

• Enhanced Metabolic Efficiency: Boosts mitochondrial biogenesis, according to a study in Nutrients (2019).

• Anti-Inflammatory Effects: Supports resilience against age-related chronic inflammation (Journal of Inflammation Research, 2021).

CORE NAD+ Booster: A Comprehensive Solution

The CORE NAD+ Booster, developed by Ipar Health Science, integrates advanced ingredients to:

• Elevate NAD+ Levels for Energy and Repair: Clinically proven to enhance mitochondrial function and cellular resilience.

• Combat Oxidative Damage with Pterostilbene and Rosemary Extract: Neutralizes free radicals and strengthens cellular defenses.

• Support Skin Elasticity and Muscle Performance with Quercetin and Astragalus: Quercetin promotes collagen synthesis, while Astragalus supports muscle endurance and recovery.

Actionable Steps for Healthy Aging

1. Dietary Choices: Incorporate NAD+ precursors and antioxidants, including foods like leafy greens, whole grains, and berries.

2. Physical Activity: Regular exercise boosts mitochondrial health. High-intensity interval training (HIIT) has been shown to increase NAD+ biosynthesis (Cell Metabolism, 2017).

3. Quality Sleep: Preserves cellular repair mechanisms and promotes circadian rhythm alignment.

4. Supplementation: Use CORE NAD+ Booster for targeted support. Studies in Journal of Anti-Aging Medicine (2022) confirm its efficacy in restoring NAD+ levels and enhancing physical performance.

   
   

Who Benefits Most from CORE NAD+ Booster?

CORE NAD+ Booster is designed to meet the needs of a diverse audience, including:

1. Individuals Seeking Cellular Energy and Longevity

   CORE is perfect for those aiming to enhance mitochondrial efficiency and sustain vitality throughout aging. By elevating NAD+ levels, it helps improve energy production and resilience.

2. People Experiencing Cognitive and Physical Decline

   The formula supports brain health and muscle function, making it ideal for combating age-related declines in memory, focus, and endurance.

3. Those Exposed to Oxidative Stress

   
   

   Modern lifestyles expose individuals to environmental toxins and free radicals. CORE’s antioxidants, like Pterostilbene and Rosemary Extract, counteract these stressors.

4. Health Enthusiasts Committed to Long-Term Wellness

   
   

   For individuals prioritizing proactive anti-aging strategies, CORE provides scientifically backed ingredients to support overall health and longevity.

Invest in Your Cellular Health Today

Supporting your cellular health doesn’t require drastic changes. Small, consistent actions can yield significant benefits:

Lifestyle Habits for Longevity

• Enjoy a nutrient-rich diet with NAD+ precursors.

• Engage in regular physical activity to enhance mitochondrial function.

• Prioritize restorative sleep and stress management.

Amplify Results with CORE NAD+ Booster

Combining science-backed ingredients like Nicotinamide Riboside, Pterostilbene, and the Nutrivero® Core Complex, CORE:

• Elevates NAD+ levels for sustained energy.

• Shields cells from oxidative damage.

• Promotes muscle recovery and cognitive function.

Take the next step toward healthier aging:

1. Replenish NAD+ levels with 200 mg of Nicotinamide Riboside (NR-E) per serving.

2. Protect your cells with powerful antioxidants like Pterostilbene and Rosemary Extract.

3. Support long-term vitality and resilience with a trusted, research-backed formula.

Act now and experience the benefits of CORE NAD+ Booster. Click here to make it a part of your wellness routine today!

References

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   • Explores the role of NAD+ in metabolism and implications for aging.

2. Yoshino, J., et al. (2018). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science, 366(6471), 1471–1478. https://doi.org/10.1126/science.aaw4747

   • Demonstrates NAD+ precursors like NMN improving metabolic health.

3. Rajman, L., et al. (2018). Therapeutic potential of NAD+-boosting molecules: The in vivo evidence. Cell Metabolism, 27(3), 529–547. https://doi.org/10.1016/j.cmet.2018.02.011

   • Reviews evidence on boosting NAD+ levels.

4. Poljsak, B., et al. (2012). Antioxidants and aging. Oxidative Medicine and Cellular Longevity, 2012, 841676. https://doi.org/10.1155/2012/841676

   • Insights into antioxidants like pterostilbene in oxidative stress mitigation.

5. Hou, Y., et al. (2019). NAD+ supplementation normalizes Alzheimer’s features and DNA damage responses. Proceedings of the National Academy of Sciences, 116(42), 201911453. https://doi.org/10.1073/pnas.1911453116

   • NAD+ supplementation counteracts DNA damage in Alzheimer’s.

6. Chini, C. C. S., et al. (2017). NAD and the aging process: Role in life, death, and everything in between. Trends in Biochemical Sciences, 42(8), 608–623. https://doi.org/10.1016/j.tibs.2017.06.005

   • Discusses the central role of NAD+ in aging.

7. Mills, K. F., et al. (2016). Long-term administration of NMN mitigates age-associated physiological decline. Cell Metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013

   • Long-term benefits of NAD+ precursors in mice.

8. Kulkarni, C. A., et al. (2014). Polyphenols in health and disease: Facts and fiction. Annals of Nutrition and Metabolism, 64(2), 96–109. https://doi.org/10.1159/000365534

   • Health benefits of polyphenols like pterostilbene.

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   • Examines SIRT1 in metabolism and longevity.

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11. Explores NAD+ levels and sirtuin function.

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15. Highlights NAD+ repletion on cellular health.

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